| Regulatory T-cells in periapical lesions. | |
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MedLine Citation:
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PMID: 19828886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD4(+)CD25(hi)Foxp3(+) regulatory T-cells (Tregs) are of crucial importance in regulating the immune response, including the control of any defense against infection. Their presence in periapical lesions has not been demonstrated, as yet. We hypothesized that Tregs infiltrate periapical lesions, where they inhibit T-cell proliferation. The aim of this study was to characterize Tregs in periapical lesions by confocal microscopy, flow cytometry, and functional assays. We showed that CD4(+)CD25(hi)Foxp3(+) cells in periapical lesions expressed IL-10 and TGF-beta. Their frequency was significantly higher than in peripheral blood and correlated with the levels of TGF-beta and IL-10 in culture supernatants of periapical lesion mononuclear cells. Tregs inhibited the proliferation of responder T-cells in vitro, at least in part, by stimulating the production of IL-10. These findings suggest that CD4(+)CD25(hi)Foxp3(+) cells in periapical lesions may play regulatory roles in controlling local immune/inflammatory processes. |
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Authors:
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M Colić; D Gazivoda; D Vucević; I Majstorović; S Vasilijić; R Rudolf; Z Brkić; P Milosavljević |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of dental research Volume: 88 ISSN: 1544-0591 ISO Abbreviation: J. Dent. Res. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: United States |
Other Details:
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Languages: eng Pagination: 997-1002 Citation Subset: D; IM |
Affiliation:
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Institute for Medical Research, Military Medical Academy, Crnotravska 17, 11002 Belgrade, Serbia. vmaimi@eunet.rs |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, CD4 / immunology CD4 Lymphocyte Count Cell Proliferation Cells, Cultured Coculture Techniques Flow Cytometry Forkhead Transcription Factors / immunology Humans Interleukin-10 / immunology Interleukin-2 Receptor alpha Subunit / immunology Leukocytes, Mononuclear / immunology Lymphocyte Activation / immunology Microscopy, Confocal Middle Aged Periapical Diseases / immunology* Receptors, Nerve Growth Factor / immunology Receptors, Tumor Necrosis Factor / immunology T-Lymphocytes, Regulatory / immunology* Transforming Growth Factor beta / immunology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/IL2RA protein, human; 0/Interleukin-2 Receptor alpha Subunit; 0/Receptors, Nerve Growth Factor; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF18 protein, human; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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