| Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis. | |
| | |
MedLine Citation:
|
PMID: 23024699 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In immune-mediated diseases, Treg and proinflammatory Th17 cells have been suggested to play either suppressor (beneficial) or effector (detrimental) roles, respectively. Tissue damage in viral infections can be caused by direct viral replication or immunopathology. Viral replication can be enhanced by anti-inflammatory responses and suppressed by proinflammatory responses. However, Tregs could suppress proinflammatory responses, reducing immunopathology, while Th17 cell-induced inflammation may enhance immunopathology. Here, the roles of Treg and Th17 cells depend on whether tissue damage is caused by direct virus replication or immunopathology, which differ depending on the virus, disease stage and host immune background. Although the precise mechanisms of tissue damage in multiple sclerosis and myocarditis are unclear, both viral replication and immune effector cells have been proposed to cause pathogenesis. Personalized medicine that alters the balance between Treg and Th17 cells may ameliorate viral pathology during infections. |
| | |
Authors:
|
Nicholas E Martinez; Fumitaka Sato; Eiichiro Kawai; Seiichi Omura; Robert P Chervenak; Ikuo Tsunoda |
Related Documents
:
|
22934809 - Therapeutic potential of cholesteryl o-acyl α-glucoside found in helicobacter pylori. 23684299 - Did cholera toxin finally get caught? 17927899 - Antioxidant and anti-hyperglycemic activity of polysaccharide isolated from dendrobium ... 21975819 - Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of artemisia cap... 16374549 - H2o2 at physiological concentrations modulates leydig cell function inducing oxidative ... 22927439 - Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine... 22719249 - The salmonella deubiquitinase ssel inhibits selective autophagy of cytosolic aggregates. 10328869 - Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokine... 16678019 - Heme oxygenase-1 attenuates the cisplatin-induced apoptosis of auditory cells via down-... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Future virology Volume: 7 ISSN: 1746-0808 ISO Abbreviation: Future Virol Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101278124 Medline TA: Future Virol Country: - |
Other Details:
|
Languages: ENG Pagination: 593-608 Citation Subset: - |
Affiliation:
|
Department of Microbiology & Immunology, Center for Molecular & Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechano-Responsive Hydrogels Crosslinked by Block Copolymer Micelles.
Next Document: The molecular biology of HIV integrase.