| Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance. | |
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MedLine Citation:
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PMID: 21726336 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Citation Ernerudh J, Berg G, Mjösberg J. Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance. Am J Reprod Immunol 2011; 66 (Suppl. 1): 31-43 Problem During pregnancy, the maternal immune system needs to adapt in order not to reject the semi-allogenic fetus. Method In this review, we describe and discuss the role of regulatory T (Treg) cells in fetal tolerance. Results Treg cells constitute a T helper lineage that is derived from thymus (natural Treg cells) or is induced in the periphery (induced Treg cells). Treg cells are enriched at the fetal-maternal interface, showing a suppressive phenotype. In contrast, Treg cells are not increased in the circulation of pregnant women, and the suppressive capacity is similar to that in non-pregnant women. However, aberrations in Treg frequencies and functions, both systemically and in the uterus, may be involved in the complications of pregnancy. Conclusion Treg cells seem to have distinguished roles locally versus systemically, based on their distribution and phenotype. |
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Authors:
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Jan Ernerudh; Göran Berg; Jenny Mjösberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 66 Suppl 1 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 31-43 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Division of Clinical Immunology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden Division of Obstetrics & Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. |
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