Document Detail


Regulatory protein Yap1 is involved in response of yeast Saccharomyces cerevisiae to nitrosative stress.
MedLine Citation:
PMID:  20632943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The goal of this work was to investigate the possible involvement of protein transcription factor Yap1 in regulation of activity of antioxidant enzymes superoxide dismutase and catalase during yeast response to nitrosative stress. It was found that the inactivation of the YAP1 gene, encoding Yap1p, cancelled the activation of superoxide dismutase and catalase by NO-donors. Then, using chimeric protein Yap1-GFP, we found the accumulation of Yap1p in the nucleus in response to nitrosative stress. Therefore, we conclude that these results in combination with previous data clearly demonstrate the involvement of Yap1p in upregulation of superoxide dismutase and catalase in yeast cells in response to nitrosative stress.
Authors:
O V Lushchak; Y Inoue; V I Lushchak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemistry. Biokhimii͡a     Volume:  75     ISSN:  1608-3040     ISO Abbreviation:  Biochemistry Mosc.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376536     Medline TA:  Biochemistry (Mosc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-64     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk, 76025, Ukraine. lushchak@pu.if.ua
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MeSH Terms
Descriptor/Qualifier:
Catalase / metabolism
Glutathione / metabolism
Nitric Oxide Donors / toxicity*
Nitroprusside / toxicity
Saccharomyces cerevisiae / drug effects,  metabolism*
Saccharomyces cerevisiae Proteins / metabolism*
Superoxide Dismutase / metabolism
Transcription Factors / metabolism*
Up-Regulation
Chemical
Reg. No./Substance:
0/Nitric Oxide Donors; 0/Saccharomyces cerevisiae Proteins; 0/Transcription Factors; 0/YAP1 protein, S cerevisiae; 15078-28-1/Nitroprusside; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

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