Document Detail

Regulatory B cells in autoimmune diseases.
MedLine Citation:
PMID:  23292280     Owner:  NLM     Status:  MEDLINE    
B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4(+) T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions in immune responses. However, certain B cells can also negatively regulate the immune response by producing regulatory cytokines and directly interacting with pathogenic T cells via cell-to-cell contact. These types of B cells are defined as regulatory B (Breg) cells. The regulatory function of Breg cells has been demonstrated in mouse models of inflammation, cancer, transplantation, and particularly in autoimmunity. In this review, we focus on the recent advances that lead to the understanding of the development and function of Breg cells and the implications of B cells in human autoimmune diseases.
Min Yang; Ke Rui; Shengjun Wang; Liwei Lu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-07
Journal Detail:
Title:  Cellular & molecular immunology     Volume:  10     ISSN:  2042-0226     ISO Abbreviation:  Cell. Mol. Immunol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-06-18     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  101242872     Medline TA:  Cell Mol Immunol     Country:  China    
Other Details:
Languages:  eng     Pagination:  122-32     Citation Subset:  IM    
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MeSH Terms
Autoimmune Diseases / immunology*,  metabolism,  pathology*
B-Lymphocyte Subsets / classification,  immunology*,  pathology*
Disease Models, Animal
Inflammation / immunology,  metabolism,  pathology
Interleukin-10 / biosynthesis,  physiology
Transforming Growth Factor beta / biosynthesis,  physiology
Reg. No./Substance:
0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10

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