Document Detail


Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.
MedLine Citation:
PMID:  18635652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4-/- mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases.
Authors:
Irena Iankova; Carine Chavey; Cyrielle Clapé; Claude Colomer; Nathalie C Guérineau; Nicolas Grillet; Jean-François Brunet; Jean-Sébastien Annicotte; Lluis Fajas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-17
Journal Detail:
Title:  Endocrinology     Volume:  149     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-01-06     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5706-12     Citation Subset:  AIM; IM    
Affiliation:
Institut National de la Santé et de la Recherche Médicale, Unité 834, Montpellier F-34298, France.
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MeSH Terms
Descriptor/Qualifier:
3T3-L1 Cells
Adipose Tissue / metabolism
Animals
Cells, Cultured
Diet, Atherogenic
Fasting / blood
Fatty Acids / blood,  metabolism*
Fatty Liver / complications,  genetics
Glucose / metabolism*
Homeostasis / genetics*
Hyperglycemia / complications,  genetics
Hyperinsulinism / complications,  genetics
Insulin / secretion
Lipogenesis / genetics
Lipolysis / genetics
Mice
Mice, Knockout
RGS Proteins / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Insulin; 0/RGS Proteins; 175335-35-0/RGS4 protein; 50-99-7/Glucose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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