Document Detail

Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration.
MedLine Citation:
PMID:  6166996     Owner:  NLM     Status:  MEDLINE    
Tissue hypoxia is a well-known stimulus to angiogenesis. The central dead space in healing wounds has been shown to be hypoxic (PO2 = 1 to 10). Angiogenesis is a necessary component of all healing wounds. Rabbit ear chambers were used to explore the contribution of O2 gradients and various inspired oxygen concentrations on wound healing and angiogenesis. These experiments demonstrate that: (1) A hypoxic tissue gradient is mandatory for wound-healing angiogenesis, (2) when the hypoxic gradient is destroyed capillary growth cases, and (3) inspired oxygen concentrations affect the rate and density of capillary growth.
D R Knighton; I A Silver; T K Hunt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  90     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-70     Citation Subset:  AIM; IM; S    
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MeSH Terms
Anoxia / physiopathology
Dose-Response Relationship, Drug
Neovascularization, Pathologic / drug effects*
Oxygen / pharmacology*
Oxygen Consumption
Wound Healing / drug effects*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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