| Regulation of vasoactive intestinal polypeptide release in the suprachiasmatic nucleus circadian clock. | |
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MedLine Citation:
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PMID: 20838260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, however, as in-vivo SCN VIP release has never been measured. Here, SCN microdialysis was used to investigate mechanisms regulating VIP. Hamsters under light-dark cycle of 14:10 exhibited a daily peak in synaptic VIP release near midday. Under constant darkness, this output was arrhythmic. Light and the glutamatergic agonist, N-methyl-D-aspartate, stimulated VIP release at night, whereas the serotonin (1A,7) agonist, (±)8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, suppressed release at midday. Hence, SCN VIP activity is stimulated by photic input and inhibited by serotonin. |
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Authors:
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Jessica M Francl; Gagandeep Kaur; John David Glass |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neuroreport Volume: 21 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2011-08-15 Revised Date: 2011-11-23 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1055-9 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Kent State University, Kent, Ohio 44242, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Clocks / drug effects, physiology* Circadian Rhythm / drug effects, physiology* Cricetinae Male Mesocricetus Microdialysis / methods Neurons / drug effects, metabolism, secretion* Photic Stimulation / methods Suprachiasmatic Nucleus / drug effects, metabolism, secretion* Vasoactive Intestinal Peptide / metabolism, secretion* |
| Grant Support | |
ID/Acronym/Agency:
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NS35229/NS/NINDS NIH HHS; R01 NS035229-12/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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