Document Detail


THE REGULATION OF UREA-BIOSYNTHESIS ENZYMES IN VERTEBRATES.
MedLine Citation:
PMID:  14343146     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Carbamoyl phosphate synthetase, ornithine transcarbamoylase, the arginine-synthetase system and arginase were measured in the livers of ammoniotelic, ureotelic and uricotelic animals. The chelonian reptiles, whose nitrogen excretory patterns vary according to the habitat, and the Mexican axolotl, a neotenic species, were also studied. 2. The levels of the activities of the first three enzymes mentioned correlate with the amount of nitrogen excreted as urea. 3. The terrestrial turtle, which excretes mainly uric acid, maintains a high arginase activity but has very low levels of the activities of the other three enzymes. 4. The first three enzymes of the urea cycle vary in the phylogenic scale in a co-ordinated manner, which suggests that they are under the same regulatory mechanism. 5. Urea formation from endogenous arginine in vitro has a low efficiency in the Mexican axolotl. 6. The induction of metamorphosis in the Mexican axolotl by the administration of l-tri-iodothyronine, which causes a shift from ammonio-ureotelism to complete ureotelism, is accompanied by an increase mainly in carbamoyl phosphate synthetase and also by an improvement in the efficiency of hydrolysis of endogenous arginine in vitro to give urea. 7. The results obtained by differential centrifugation of the urea-cycle enzymes in rat and Mexican-axolotl livers are presented. The location requirements for the integration of a metabolic cycle are discussed.
Authors:
J MORA; J MARTUSCELLI; J ORTIZ PINEDA; G SOBERON
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  96     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1965 Jul 
Date Detail:
Created Date:  1965-12-01     Completed Date:  1996-12-01     Revised Date:  2011-09-28    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism*
Anura*
Arginase*
Arginine*
Biological Evolution*
Fluids and Secretions*
Ligases*
Liver / enzymology*
Metabolism*
Mice*
Microsomes*
Ornithine Carbamoyltransferase*
Physiology, Comparative*
Rats*
Reptiles*
Research*
Species Specificity*
Urea*
Urodela*
Vertebrates*
Chemical
Reg. No./Substance:
0/Amino Acids; 57-13-6/Urea; 74-79-3/Arginine; EC 2.1.3.3/Ornithine Carbamoyltransferase; EC 3.5.3.1/Arginase; EC 6.-/Ligases
Comments/Corrections

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