| Regulation of type II fatty acid synthase in Gram-positive bacteria. | |
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MedLine Citation:
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PMID: 18372209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial cells stringently regulate the synthesis of their membrane phospholipids but the responsible mechanisms are incompletely understood. Recent biochemical, genetic and structural analyses have greatly expanded the knowledge of lipid metabolism in Gram-positive bacteria, revealing that these organisms use novel mechanisms to regulate this essential pathway. A remarkable progress was the identification of a new pathway for the initiation of phospholipid biosynthesis that uncovered a mechanism that coordinates fatty acid and phospholipid biosynthesis. Recent advances in structure determination of a global transcription factor have led to significant insights of the underlying complexities and functional elegance of membrane lipid homeostasis in Gram-positive bacteria. |
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Authors:
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Gustavo E Schujman; Diego de Mendoza |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-03-26 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 11 ISSN: 1369-5274 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-21 Completed Date: 2008-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 148-52 Citation Subset: IM |
Affiliation:
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Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET) and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. schujman@ibr.gov.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Fatty Acid Synthetase Complex, Type II
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genetics,
metabolism* Gene Expression Regulation, Bacterial* Gram-Positive Bacteria / enzymology*, genetics Membrane Lipids / biosynthesis*, chemistry Models, Molecular Phospholipids / biosynthesis Transcription Factors / chemistry, genetics, metabolism Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Membrane Lipids; 0/Phospholipids; 0/Transcription Factors; EC 6.-/Fatty Acid Synthetase Complex, Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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