Document Detail


Regulation of type II fatty acid synthase in Gram-positive bacteria.
MedLine Citation:
PMID:  18372209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacterial cells stringently regulate the synthesis of their membrane phospholipids but the responsible mechanisms are incompletely understood. Recent biochemical, genetic and structural analyses have greatly expanded the knowledge of lipid metabolism in Gram-positive bacteria, revealing that these organisms use novel mechanisms to regulate this essential pathway. A remarkable progress was the identification of a new pathway for the initiation of phospholipid biosynthesis that uncovered a mechanism that coordinates fatty acid and phospholipid biosynthesis. Recent advances in structure determination of a global transcription factor have led to significant insights of the underlying complexities and functional elegance of membrane lipid homeostasis in Gram-positive bacteria.
Authors:
Gustavo E Schujman; Diego de Mendoza
Related Documents :
17096349 - Familial adenomatous polyposis patients have high levels of arachidonic acid and docosa...
22652809 - Nutritional and regulatory role of branched-chain amino acids in lactation.
11818229 - Palmitate and oleate metabolism of rainbow trout in vivo.
894359 - Effect of dietary fats on oxidative phosphorylation and fatty acid profile of rat liver...
2106009 - Arachidonic acid incorporation and redistribution in human neuroblastoma (sk-n-be) cell...
7547929 - Fatty acid flip-flop in phospholipid bilayers is extremely fast.
22609809 - Antinociceptive activity of aqueous extract and isolated compounds of lithrea molleoides.
15595449 - Nmr assignments of the major cannabinoids and cannabiflavonoids isolated from flowers o...
17116579 - Utilization of shochu distillery wastewater for production of polyunsaturated fatty aci...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-26
Journal Detail:
Title:  Current opinion in microbiology     Volume:  11     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
Affiliation:
Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET) and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. schujman@ibr.gov.ar
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Fatty Acid Synthetase Complex, Type II / genetics,  metabolism*
Gene Expression Regulation, Bacterial*
Gram-Positive Bacteria / enzymology*,  genetics
Membrane Lipids / biosynthesis*,  chemistry
Models, Molecular
Phospholipids / biosynthesis
Transcription Factors / chemistry,  genetics,  metabolism
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
//Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Membrane Lipids; 0/Phospholipids; 0/Transcription Factors; EC 6.-/Fatty Acid Synthetase Complex, Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Plant pathogenic bacterial type III effectors subdue host responses.
Next Document:  Evaluation of the genotoxicity of piplartine, an alkamide of Piper tuberculatum, in yeast and mammal...