Document Detail

Regulation of type II fatty acid synthase in Gram-positive bacteria.
MedLine Citation:
PMID:  18372209     Owner:  NLM     Status:  MEDLINE    
Bacterial cells stringently regulate the synthesis of their membrane phospholipids but the responsible mechanisms are incompletely understood. Recent biochemical, genetic and structural analyses have greatly expanded the knowledge of lipid metabolism in Gram-positive bacteria, revealing that these organisms use novel mechanisms to regulate this essential pathway. A remarkable progress was the identification of a new pathway for the initiation of phospholipid biosynthesis that uncovered a mechanism that coordinates fatty acid and phospholipid biosynthesis. Recent advances in structure determination of a global transcription factor have led to significant insights of the underlying complexities and functional elegance of membrane lipid homeostasis in Gram-positive bacteria.
Gustavo E Schujman; Diego de Mendoza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-26
Journal Detail:
Title:  Current opinion in microbiology     Volume:  11     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET) and Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina.
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MeSH Terms
Fatty Acid Synthetase Complex, Type II / genetics,  metabolism*
Gene Expression Regulation, Bacterial*
Gram-Positive Bacteria / enzymology*,  genetics
Membrane Lipids / biosynthesis*,  chemistry
Models, Molecular
Phospholipids / biosynthesis
Transcription Factors / chemistry,  genetics,  metabolism
Transcription, Genetic
Grant Support
//Howard Hughes Medical Institute
Reg. No./Substance:
0/Membrane Lipids; 0/Phospholipids; 0/Transcription Factors; EC 6.-/Fatty Acid Synthetase Complex, Type II

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