Document Detail


Regulation of type 1 iodothyronine deiodinase in health and disease.
MedLine Citation:
PMID:  16131326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The major physiologic function of type 1 iodothyronine deiodinase (D1) is to produce triiodothyronine (T(3)) for the plasma. D1 activity is regulated by numerous factors, perhaps the most important of which in human pathophysiology is T(3). T(3) induces D1 expression, contributing to the T(3) excess commonly found in hyperthyroidism. Cytokines, nutritional status, sex steroids, and other factors also regulate D1 activity, although different organs often show different responses. Numerous homeostatic mechanisms can counterbalance isolated changes in D1 expression, such as the genetically decreased expression in C3H/He mice. Two relatively commonly used drugs, propylthiouracil and amiodarone, inhibit D1, which can have substantial effects on circulating thyroid hormone levels. Overall, many factors interact in complex ways to establish D1 levels, contributing to the circulating concentrations of thyroxine (T(4)) and T(3).
Authors:
Ronald J Koenig
Related Documents :
11313986 - Regulation of the cdc25a gene by the human papillomavirus type 16 e7 oncogene.
18656336 - Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expr...
8628726 - Helical fold prediction for the cyclin box.
18408756 - E2f1 regulates autophagy and the transcription of autophagy genes.
8584456 - Inhibition of oncogene expression by green tea and (-)-epigallocatechin gallate in mice.
18680616 - The role of native bovine alpha-lactalbumin in bovine mammary epithelial cell apoptosis...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  15     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-31     Completed Date:  2006-04-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  835-40     Citation Subset:  IM    
Affiliation:
University of Michigan, Ann Arbor, Michigan 48109, USA. rkoenig@umich.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm
Eating
Feeding Behavior
Gene Expression Regulation, Enzymologic*
Humans
Iodide Peroxidase / biosynthesis*
Liver / metabolism
Mice
Mice, Inbred C3H
Selenium / deficiency
Steroids / metabolism
Thyroid Diseases / metabolism
Thyroid Hormones / metabolism
Triiodothyronine / metabolism
Grant Support
ID/Acronym/Agency:
R01 DK44155/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Steroids; 0/Thyroid Hormones; 6893-02-3/Triiodothyronine; 7782-49-2/Selenium; EC 1.11.1.-/iodothyronine deiodinase type I; EC 1.11.1.8/Iodide Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The roles of the iodothyronine deiodinases in mammalian development.
Next Document:  Selenium and the control of thyroid hormone metabolism.