Document Detail

Regulation of the G2/M transition in rodent oocytes.
MedLine Citation:
PMID:  20578061     Owner:  NLM     Status:  MEDLINE    
Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell-cell coupling pathways. This review highlights recent advances in our understanding of how such signaling controls both meiotic arrest and gonadotropin-triggered meiotic resumption in competent oocytes and relates them to the historical context. Emphasis will be on rodent systems, where many of these new findings have taken place. A regulatory scheme is then proposed that integrates this information into an overall framework for meiotic regulation that demonstrates the complex interplay between different follicular compartments.
Stephen M Downs
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular reproduction and development     Volume:  77     ISSN:  1098-2795     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-10-08     Revised Date:  2014-04-24    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-85     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
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MeSH Terms
Cell Division / physiology*
G2 Phase / physiology*
Oocytes / physiology*
Signal Transduction / physiology*
Grant Support

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