Document Detail

Regulation of stress granules in virus systems.
MedLine Citation:
PMID:  22405519     Owner:  NLM     Status:  MEDLINE    
Virus infection initiates a number of cellular stress responses that modulate gene regulation and compartmentalization of RNA. Viruses must control host gene expression and the localization of viral RNAs to be successful parasites. RNA granules such as stress granules and processing bodies (PBs) contain translationally silenced messenger ribonucleoproteins (mRNPs) and serve as extensions of translation regulation in cells, storing transiently repressed mRNAs. New reports show a growing number of virus families modulate RNA granule function to maximize replication efficiency. This review summarizes recent advances in understanding the relationship between viruses and mRNA stress granules in animal cells and will discuss important questions that remain in this emerging field.
James P White; Richard E Lloyd
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-03-07
Journal Detail:
Title:  Trends in microbiology     Volume:  20     ISSN:  1878-4380     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-07-27     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Cytoplasmic Granules / metabolism*
Gene Expression Regulation*
Gene Silencing*
Host-Pathogen Interactions*
Protein Biosynthesis
RNA, Messenger / metabolism*
Stress, Physiological
Viruses / pathogenicity*
Grant Support
Reg. No./Substance:
0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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