Document Detail


Regulation of steroidogenesis by Cordyceps sinensis mycelium extracted fractions with (hCG) treatment in mouse Leydig cells.
MedLine Citation:
PMID:  17453685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro effect of extracted fractions of Cordyceps sinensis (CS) mycelium on hCG-treated testosterone production from purified normal mouse Leydig cells was examined. Different fractions extracted from CS (F1-water soluble polysaccharide, F2- water soluble protein and F3- poorly water soluble polysaccharide, and protein) were added to Leydig cells with hCG, and the production of testosterone was determined by radioimmunoassay (RIA). Testosterone productions stimulated by hCG in mouse Leydig cells were suppressed by F2 at 10 mg/ml and F3 at doses from 3 to 10 mg/ml, respectively. F2 and F3 at 10 mg/ml did inhibit dbcAMP-stimulated testosterone productions which indicated that F2 and F3 might affect steroidogenesis at the site after the formation of cyclic AMP. Finally, cycloheximide inhibited F2- and F3-treated mouse Leydig cell testosterone production.
Authors:
K L Wong; E Cheung So; C C Chen; R S C Wu; B-M Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of andrology     Volume:  53     ISSN:  0148-5016     ISO Abbreviation:  Arch. Androl.     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806755     Medline TA:  Arch Androl     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, Pain Management and Critical Care Medicine, China Medical University and Hospital. Taichung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bucladesine / pharmacology
Chorionic Gonadotropin / pharmacology
Cordyceps / drug effects,  isolation & purification,  physiology*
Leydig Cells / drug effects,  microbiology*,  physiology
Male
Mice
Steroids / biosynthesis*
Testosterone / biosynthesis*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Steroids; 362-74-3/Bucladesine; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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