Document Detail

Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line.
MedLine Citation:
PMID:  14719077     Owner:  NLM     Status:  MEDLINE    
Squamous cell carcinoma antigen (SCCA) is a useful tumor marker for diagnosis and management of squamous cell carcinoma. It is well known that cell-cell adhesion is important for progression of cancer. However, it is not clarified whether cell-cell adhesion affects SCCA production in squamous cell carcinoma. The present study was, therefore, undertaken to investigate whether E-cadherin-mediated cell-cell adhesion affects SCCA production in squamous cell carcinoma of the uterine cervix. SKG-IIIa cells or CaSki cells, cervical squamous cell carcinoma cell lines, were treated with anti-E-cadherin antibodies (1 microg/ml) up to 72 h. The cells were dissociated, and SCCA content in the cytosol and SCCA mRNA levels were significantly decreased compared to the control group treated with mouse IgG. Secondly, the signaling pathway for SCCA production mediated by E-cadherin was examined. Phosphatidylinositol (PI) 3-kinase is a well-known mediator of E-cadherin-mediated biological events. The treatment with a PI 3-kinase inhibitor suppressed SCCA production in SKG-IIIa cells. It is concluded that E-cadherin mediated cell-cell adhesion maintains SCCA production through PI 3-kinase in squamous cell carcinoma.
Hiroshi Hirakawa; Shugo Nawata; Kotaro Sueoka; Akihiro Murakami; Osamu Takeda; Fumitaka Numa; Hiroshi Kato; Norihiro Sugino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  11     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-13     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  IM    
Division of Obstetrics and Gynecology, Department of Reproductive Pediatric and Infectious Science, Yamaguchi University School of Medicine, 1-1-1 Minami-kogushi, Ube 755-8505, Japan.
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MeSH Terms
1-Phosphatidylinositol 3-Kinase / metabolism
Antibodies, Neoplasm / pharmacology
Antigens, Neoplasm / biosynthesis*,  immunology,  physiology*
Cadherins / physiology*
Carcinoma, Squamous Cell / immunology*,  physiopathology
Cell Adhesion / physiology*
Cell Line, Tumor
Serpins / immunology,  physiology*
Uterine Cervical Neoplasms
Reg. No./Substance:
0/Antibodies, Neoplasm; 0/Antigens, Neoplasm; 0/Cadherins; 0/Serpins; 0/squamous cell carcinoma-related antigen; EC 3-Kinase

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