| Regulation of spatiotemporal expression of cell-cell adhesion molecules during development of Dictyostelium discoideum. | |
| | |
MedLine Citation:
|
PMID: 21585356 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The social amoeba Dictyostelium discoideum is a simple but powerful model organism for the study of cell-cell adhesion molecules and their role in morphogenesis during development. Three adhesive systems have been characterized and studied in detail. The spatiotemporal expression of these adhesion proteins is stringently regulated, often coinciding with major shifts in the morphological complexity of development. At the onset of development, amoeboid cells express the Ca(2+) -dependent cell-cell adhesion molecule DdCAD-1, which initiates weak homophilic interactions between cells and assists in the recruitment of individuals into cell streams. DdCAD-1 is unique because it is synthesized as a soluble protein in the cytoplasm. It is targeted for presentation on the cell surface by an unconventional protein transport mechanism via the contractile vacuole. Concomitant with the aggregation stage is the expression of the contact sites A glycoprotein csA/gp80 and TgrC1, both of which mediate Ca(2+) /Mg(2+) -independent cell-cell adhesion. Whereas csA/gp80 is a homophilic binding protein, TgrC1 binds to a heterophilic receptor on the cell. During cell aggregation, csA/gp80 associates preferentially with lipid rafts, which facilitate the rapid assembly of adhesion complexes. TgrC1 is synthesized at low levels during aggregation and rapid accumulation occurs initially in the peripheral cells of loose mounds. The extracellular portion of TgrC1 is shed and becomes part of the extracellular matrix. Additionally, analyses of knockout mutants have revealed important biological roles played by these adhesion proteins, including size regulation, cell sorting and cell-type proportioning. |
| | |
Authors:
|
Chi-Hung Siu; Shrivani Sriskanthadevan; Jun Wang; Liansheng Hou; Gong Chen; Xiaoqun Xu; Alexander Thomson; Chunxia Yang |
Related Documents
:
|
21722586 - Glycated albumin modulates endothelial cell thrombogenic and inflammatory responses. 21298436 - Regulation of vascular guanylyl cyclase by endothelial nitric oxide-dependent posttrans... 21912546 - In vitro properties of orthodontic adhesives with fluoride or amorphous calcium phosphate. 21776386 - Individual rac gtpases mediate aspects of prostate cancer cell and bone marrow endothel... 12074266 - Clinical importance of endothelial function in arteriosclerosis and ischemic heart dise... 16648176 - Vascular reactivity and endothelial nos activity in rat thoracic aorta during and after... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Development, growth & differentiation Volume: 53 ISSN: 1440-169X ISO Abbreviation: Dev. Growth Differ. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0356504 Medline TA: Dev Growth Differ Country: Japan |
Other Details:
|
Languages: eng Pagination: 518-27 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. Development, Growth & Differentiation © 2011 Japanese Society of Developmental Biologists. |
Affiliation:
|
Banting and Best Department of Medical Research and Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Collective oscillations in developing cells: Insights from simple systems.
Next Document: Cell migration in multicellular environments.