| Regulation of somatostatin-14 and gastrin I binding sites in rat gastrointestinal mucosa by ulcerogenic dose of cysteamine. | |
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MedLine Citation:
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PMID: 2883547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single duodenal ulcerogenic dose of cysteamine administered into rats induced time-dependent depletion of immunoreactive somatostatin in the gastric corporeal, antral, and duodenal mucosa with a parallel increase (up-regulation) of somatostatin binding sites. The concentration of somatostatin binding sites returned to the control level in the corporeal mucosa when measured at 24 hrs; however, in the duodenal mucosa there was only a partial return to the control level. Somatostatin binding sites in the antral mucosa did not return to control level even after 24 hrs. Except for the duodenum mucosal immunoreactive gastrin level was unaffected by cysteamine administration, but corporeal mucosal gastrin I binding sites were diminished (down-regulation) after 24 hrs. |
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Authors:
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W J Rossowski; A Ozden; A Ertan; A Arimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 40 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-15 Completed Date: 1987-06-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1783-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cysteamine / toxicity* Duodenal Ulcer / chemically induced Gastric Mucosa / analysis, drug effects* Gastrins / metabolism* Intestinal Mucosa / analysis, drug effects* Male Rats Rats, Inbred Strains Receptors, Cholecystokinin / analysis*, drug effects Receptors, Neurotransmitter / analysis*, drug effects Receptors, Somatostatin Somatostatin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AM09094/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 0/Receptors, Cholecystokinin; 0/Receptors, Neurotransmitter; 0/Receptors, Somatostatin; 51110-01-1/Somatostatin; 60-23-1/Cysteamine; 9045-90-3/gastrin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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