Document Detail

Regulation of somatostatin-14 and gastrin I binding sites in rat gastrointestinal mucosa by ulcerogenic dose of cysteamine.
MedLine Citation:
PMID:  2883547     Owner:  NLM     Status:  MEDLINE    
A single duodenal ulcerogenic dose of cysteamine administered into rats induced time-dependent depletion of immunoreactive somatostatin in the gastric corporeal, antral, and duodenal mucosa with a parallel increase (up-regulation) of somatostatin binding sites. The concentration of somatostatin binding sites returned to the control level in the corporeal mucosa when measured at 24 hrs; however, in the duodenal mucosa there was only a partial return to the control level. Somatostatin binding sites in the antral mucosa did not return to control level even after 24 hrs. Except for the duodenum mucosal immunoreactive gastrin level was unaffected by cysteamine administration, but corporeal mucosal gastrin I binding sites were diminished (down-regulation) after 24 hrs.
W J Rossowski; A Ozden; A Ertan; A Arimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  40     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1783-9     Citation Subset:  IM    
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MeSH Terms
Cysteamine / toxicity*
Duodenal Ulcer / chemically induced
Gastric Mucosa / analysis,  drug effects*
Gastrins / metabolism*
Intestinal Mucosa / analysis,  drug effects*
Rats, Inbred Strains
Receptors, Cholecystokinin / analysis*,  drug effects
Receptors, Neurotransmitter / analysis*,  drug effects
Receptors, Somatostatin
Somatostatin / metabolism*
Grant Support
Reg. No./Substance:
0/Gastrins; 0/Receptors, Cholecystokinin; 0/Receptors, Neurotransmitter; 0/Receptors, Somatostatin; 51110-01-1/Somatostatin; 60-23-1/Cysteamine; 9045-90-3/gastrin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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