Document Detail

Regulation of somatostatin-14 and gastrin I binding sites in rat gastrointestinal mucosa by ulcerogenic dose of cysteamine.
MedLine Citation:
PMID:  2883547     Owner:  NLM     Status:  MEDLINE    
A single duodenal ulcerogenic dose of cysteamine administered into rats induced time-dependent depletion of immunoreactive somatostatin in the gastric corporeal, antral, and duodenal mucosa with a parallel increase (up-regulation) of somatostatin binding sites. The concentration of somatostatin binding sites returned to the control level in the corporeal mucosa when measured at 24 hrs; however, in the duodenal mucosa there was only a partial return to the control level. Somatostatin binding sites in the antral mucosa did not return to control level even after 24 hrs. Except for the duodenum mucosal immunoreactive gastrin level was unaffected by cysteamine administration, but corporeal mucosal gastrin I binding sites were diminished (down-regulation) after 24 hrs.
W J Rossowski; A Ozden; A Ertan; A Arimura
Related Documents :
7716277 - Interactions between npy and its receptor: assessment using ant-npy antibodies.
1731167 - Identification and characterization of melatonin binding sites in the gastrointestinal ...
1649257 - Guanine nucleotides regulate 2-[125i]iodomelatonin binding sites in chick retinal pigme...
1968467 - Evaluation of receptors for somatostatin in various tumors using different analogs.
9316667 - Environmental stress-induced functional modification of the central benzodiazepine bind...
6307297 - Effect of dithiothreitol on the 1 alpha, 25-dihydroxyvitamin d3 chick intestinal recept...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  40     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1783-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cysteamine / toxicity*
Duodenal Ulcer / chemically induced
Gastric Mucosa / analysis,  drug effects*
Gastrins / metabolism*
Intestinal Mucosa / analysis,  drug effects*
Rats, Inbred Strains
Receptors, Cholecystokinin / analysis*,  drug effects
Receptors, Neurotransmitter / analysis*,  drug effects
Receptors, Somatostatin
Somatostatin / metabolism*
Grant Support
Reg. No./Substance:
0/Gastrins; 0/Receptors, Cholecystokinin; 0/Receptors, Neurotransmitter; 0/Receptors, Somatostatin; 51110-01-1/Somatostatin; 60-23-1/Cysteamine; 9045-90-3/gastrin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of chronic ethanol treatment on amino acid uptake and enzyme activities in the lactating rat...
Next Document:  Adrenoceptors and the pharmacology of affective illness: a unifying theory.