| Regulation of skeletal muscle proteolysis by amino acids. | |
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MedLine Citation:
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PMID: 15648001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal muscle is the major reservoir of body protein that can be mobilized in a number of muscle wasting conditions, that include kidney failure. Increased proteolysis in such conditions provides free amino acids that are used for acute-phase protein synthesis or that are degraded for energy purposes. Amino acids act as signals to regulate both protein synthesis and protein breakdown. We review the current but limited information available on the regulation of proteolytic systems in muscle cells. In particular, recent data have shown that amino acid deprivation in C2C12 myotubes stimulates autophagic sequestration by mechanisms that implicate the Apg system through a class III phosphoinositide-3'-kinase (PI3K III ) signaling cascade. |
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Authors:
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Daniel Béchet; Amina Tassa; Lydie Combaret; Daniel Taillandier; Didier Attaix |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation Volume: 15 ISSN: 1532-8503 ISO Abbreviation: J Ren Nutr Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-13 Completed Date: 2006-08-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9112938 Medline TA: J Ren Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 18-22 Citation Subset: IM |
Affiliation:
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Human Nutrition Research Center of Clermont-Ferrand, Nutrition and Protein Metabolism Unit, INRA de Theix, Ceyrat, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Amino Acids / deficiency, physiology* Animals Autophagy Calpain / metabolism Caspases / metabolism Homeostasis Humans Lysosomes / enzymology Matrix Metalloproteinase 2 / metabolism Muscle Fibers, Skeletal / enzymology Muscle Proteins / metabolism* Muscle, Skeletal / enzymology* Proteasome Endopeptidase Complex / metabolism Signal Transduction Ubiquitin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Muscle Proteins; 0/Ubiquitin; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 3.4.22.-/Calpain; EC 3.4.22.-/Caspases; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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