Document Detail


Regulation of secretory type-II phospholipase A2 and of lysophosphatidic acid synthesis.
MedLine Citation:
PMID:  9762349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secretory non-pancreatic phospholipase A2 (sPLA2), also called type II-PLA2, is produced in large amounts under inflammatory conditions, thus accumulating in inflammatory fluids. Since the enzyme is virtually inactive on phospholipids from intact cells, we have searched for conditions allowing the action of sPLA2 on membrane phospholipids. Based on an in vitro model, our studies suggest that only those membranes where the transverse distribution of phospholipids has been disturbed offer a convenient surface able to interact with the enzyme, which then achieves significant degradation of all glycerophospholipids. This results in the accumulation of various lysophospholipids such as lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. However, lysophosphatidic acid (LPA) can also be generated under these conditions involving accumulation of phosphatidic acid in the cytoplasmic leaflet of the membrane, followed by its transfer to the outer monolayer. Since LPA is now considered as a novel phospholipid mediator, this pathway deserves further studies concerning mainly platelets, the main source of LPA identified so far.
Authors:
O Fourcade; F Le Balle; J Fauvel; M F Simon; H Chap
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in enzyme regulation     Volume:  38     ISSN:  0065-2571     ISO Abbreviation:  Adv. Enzyme Regul.     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-18     Completed Date:  1998-12-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0044263     Medline TA:  Adv Enzyme Regul     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-107     Citation Subset:  IM    
Affiliation:
Institut Fédératif de Recherche en Immunologie Cellulaire et Moléculaire, Université Paul Sabatier and Centre Hospitalo-Universitaire de Toulouse, INSERM Unité 326, Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Erythrocytes / metabolism
Group II Phospholipases A2
Inflammation / metabolism
Lysophospholipids / biosynthesis*
Mammals
Membrane Lipids / metabolism
Phospholipases A / metabolism*
Phospholipases A2
Phospholipids / metabolism
Chemical
Reg. No./Substance:
0/Lysophospholipids; 0/Membrane Lipids; 0/Phospholipids; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Group II Phospholipases A2; EC 3.1.1.4/Phospholipases A2

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