Document Detail

Regulation of renin release by local and systemic factors.
MedLine Citation:
PMID:  22128405     Owner:  NLM     Status:  MEDLINE    
The renin-angiotensin system (RAS) is critically involved in the regulation of the salt and volume status of the body and blood pressure. The activity of the RAS is controlled by the protease renin, which is released from the renal juxtaglomerular epithelioid cells into the circulation. Renin release is regulated in negative feedback-loops by blood pressure, salt intake, and angiotensin II. Moreover, sympathetic nerves and renal autacoids such as prostaglandins and nitric oxide stimulate renin secretion. Despite numerous studies there remained substantial gaps in the understanding of the control of renin release at the organ or cellular level. Some of these gaps have been closed in the last years by means of gene-targeted mice and advanced imaging and electrophysiological methods. In our review, we discuss these recent advances together with the relevant previous literature on the regulation of renin release.
F Schweda; A Kurtz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of physiology, biochemistry and pharmacology     Volume:  161     ISSN:  0303-4240     ISO Abbreviation:  Rev. Physiol. Biochem. Pharmacol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-29     Completed Date:  2011-12-15     Revised Date:  2012-07-26    
Medline Journal Info:
Nlm Unique ID:  0434624     Medline TA:  Rev Physiol Biochem Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-44     Citation Subset:  IM    
Institut für Physiologie, Universität Regensburg, 93040 Regensburg, Germany.
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MeSH Terms
Atrial Natriuretic Factor / physiology
Blood Pressure
Calcium / metabolism
Cell Communication
Cyclic GMP / physiology
Pressoreceptors / physiology
Renin / metabolism*
Signal Transduction
Sodium Chloride / pharmacology
Reg. No./Substance:
7440-70-2/Calcium; 7647-14-5/Sodium Chloride; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC

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