| Regulation of rat alpha-fetoprotein production by methionine during ethionine-hepatocarcinogenesis. | |
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MedLine Citation:
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PMID: 6174466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of serum alpha-fetoprotein (AFP) in rats were determined during hepatocarcinogenesis with ethionine, and the effects of methionine administration on serum AFP elevation in these animals were studied with the aim of investigating regulatory mechanisms of AFP was observed 6 weeks following the start of feeding a diet containing 0.25% ethionine and again at the 22nd week of feeding, when a well-differentiated hepatoma had already developed. These biphasic elevations of serum AFP concentrations in rats fed a 0.25% ethionine-containing diet decreased abruptly an significantly following a change to the basal diet either supplemented with or without 0.7% methionine. The possibility that regulation of AFP production in these rats may correlate with methionine metabolisms is discussed on the basis of the experimental data obtained. |
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Authors:
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M Miyazaki; A Watanabe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 29 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: DENMARK |
Other Details:
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Languages: eng Pagination: 213-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet Ethionine Female Liver Neoplasms / chemically induced*, metabolism Methionine / administration & dosage* Rats Rats, Inbred Strains Time Factors alpha-Fetoproteins / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins; 13073-35-3/Ethionine; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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