Document Detail

Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise.
MedLine Citation:
PMID:  11991544     Owner:  NLM     Status:  MEDLINE    
Pyruvate dehydrogenase is a mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A and regulates the entry of carbohydrate into the tricarboxylic acid cycle for oxidation. During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent VO2max) and is regulated by increases in Ca2+, free ADP, and pyruvate concentrations.
Lawrence L Spriet; George J F Heigenhauser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Exercise and sport sciences reviews     Volume:  30     ISSN:  0091-6331     ISO Abbreviation:  Exerc Sport Sci Rev     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375434     Medline TA:  Exerc Sport Sci Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada.
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MeSH Terms
Acetyl Coenzyme A / metabolism
Adenosine Triphosphate / metabolism
Carbohydrate Metabolism
Exercise / physiology*
Mitochondria, Muscle / metabolism*
Muscle, Skeletal / enzymology*
Oxygen / metabolism
Pyruvate Dehydrogenase Complex / metabolism*
Reg. No./Substance:
0/Pyruvate Dehydrogenase Complex; 56-65-5/Adenosine Triphosphate; 72-89-9/Acetyl Coenzyme A; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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