Document Detail

Regulation of proximal-distal intercalation during limb regeneration in the axolotl (Ambystoma mexicanum).
MedLine Citation:
PMID:  21158757     Owner:  NLM     Status:  In-Process    
Intercalation is the process whereby cells located at the boundary of a wound interact to stimulate proliferation and the restoration of the structures between the boundaries that were lost during wounding. Thus, intercalation is widely considered to be the mechanism of regeneration. When a salamander limb is amputated, the entire cascade of regeneration events is activated, and the missing limb segments and their boundaries (joints) as well as the structures within each segment are regenerated. Therefore, in an amputated limb it is not possible to distinguish between intersegmental regeneration (formation of new segments/joints) and intrasegmental regeneration (formation of structures within a given segment), and it is not possible to study the differential regulation of these two processes. We have used two models for regeneration that allow us to study these two processes independently, and report that inter- and intrasegmental regeneration are different processes regulated by different signaling pathways. New limb segments/joints can be regenerated from cells that dedifferentiate to form blastema cells in response to signaling that is mediated in part by fibroblast growth factor.
Akira Satoh; Gillian M C Cummings; Susan V Bryant; David M Gardiner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Development, growth & differentiation     Volume:  52     ISSN:  1440-169X     ISO Abbreviation:  Dev. Growth Differ.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356504     Medline TA:  Dev Growth Differ     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  785-98     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation © 2010 Japanese Society of Developmental Biologists.
Department of Developmental and Cell Biology and The Developmental Biology Center, University of California Irvine, Irvine, CA 92697-2305, USA.
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