Document Detail

Regulation of protein metabolism by glutamine: implications for nutrition and health.
MedLine Citation:
PMID:  21196190     Owner:  NLM     Status:  MEDLINE    
Glutamine is the most abundant free alpha-amino acid in plasma and skeletal muscle. This nutrient plays an important role in regulating gene expression, protein turnover, anti-oxidative function, nutrient metabolism, immunity, and acid-base balance. Interestingly, intracellular and extracellular concentrations of glutamine exhibit marked reductions in response to infection, sepsis, severe burn, cancer, and other pathological factors. This raised an important question of whether glutamine may be a key mediator of muscle loss and negative nitrogen balance in critically ill and injured patients. Therefore, since the initial reports in late 1980s that glutamine could stimulate protein synthesis and inhibit proteolysis in rat skeletal muscle, there has been growing interest in the use of this functional amino acid to improve protein balance under various physiological and disease conditions. Although inconsistent results have appeared in the literature regarding a therapeutic role of glutamine in clinical medicine, a majority of studies indicate that supplementing appropriate doses of glutamine to enteral diets or parenteral solutions is beneficial for improving nitrogen balance in animals or humans with glutamine deficiency.
Pengbin Xi; Zongyong Jiang; Chuntian Zheng; Yingcai Lin; Guoyao Wu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  16     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-21     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  578-97     Citation Subset:  IM    
Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science South China and Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Tianhe District, Wushan Road, Guangzhou, Guangdong, PR China.
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MeSH Terms
Burns / physiopathology
Critical Illness
Dietary Supplements
Glutamine / metabolism,  physiology*,  therapeutic use
Infant, Newborn
Infant, Very Low Birth Weight
Malnutrition / physiopathology
Muscle, Skeletal / metabolism
Muscular Dystrophy, Duchenne / physiopathology
Neoplasms / physiopathology
Nutritional Sciences
Proteins / metabolism*
Sepsis / chemically induced,  physiopathology
Grant Support
Reg. No./Substance:
0/Proteins; 56-85-9/Glutamine

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