Document Detail

Regulation of pressure-activated channel in intact vascular endothelium of stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  11465659     Owner:  NLM     Status:  MEDLINE    
The pressure-activated cation channel (PAC), a novel type of mechanosensitive channel, has been suggested to act as a mechanosensor in aortic endothelium. In experimental hypertension, PAC function was up-regulated in the established phase of high blood pressure. This association of altered PAC function and elevated arterial pressure suggests that PAC function is regulated by alterations in blood pressure. In the present study, we electrophysiologically investigated PAC function in intact endothelium of aorta (EA) and mesenteric artery (EMA) from stroke-prone spontaneously hypertensive rats (SHRSP), SHRSP after 4 weeks of treatment with quinaprilat (10 mg/kg/day), and normotensive Wistar-Kyoto (WKY) rats. In untreated SHRSP and WKY rats, systolic blood pressure (SBP) was 201+/-3 mm Hg and 142+/-3 mm Hg, respectively. In quinaprilat-treated SHRSP, SBP was lowered to 135+/-5 mm Hg. Apparent PAC density (percentage of patches with PAC activity) in EA of untreated SHRSP (63.7%+/-7.3%) was 2.4-fold higher than in WKY rats (26.0%+/-5.0%). In contrast, no significant PAC up-regulation was detected in EMA of SHRSP (15.7%+/-4.2%) compared with WKY rats (12.0%+/-3.9%). In EA of quinaprilat-treated normotensive SHRSP, PAC density (27.1%+/-5.2%) was lowered to levels found in normotensive WKY rats. Unitary conductance and pressure sensitivity of PAC were not altered in either hypertensive or normotensive rats. Taken together, hypertension-induced increases of endothelial PAC density can be completely reversed by antihypertensive therapy. The PAC up-regulation in EA was interpreted as a compensatory mechanism to enhance Ca2+-influx and subsequently the synthesis of vasodilatory factors. This mechanism is missing in EMA of SHRSP, which might contribute to high blood pressure in this rat model of severe genetic hypertension.
R Köhler; A Grundig; S Brakemeier; L Rothermund; A Distler; R Kreutz; J Hoyer
Related Documents :
15448879 - Myocardial contractility of the isovolumetrically beating isolated rat heart.
3241239 - Effect on blood pressure of chemically induced renomedullectomy in normotensive and spo...
19731009 - Blood pressure-independent factors determine the susceptibility to delayed neuronal dea...
12600899 - Gene transfer of extracellular superoxide dismutase reduces arterial pressure in sponta...
8963689 - Microinfusion of aminopeptidase m into the paraventricular nucleus of the hypothalamus ...
8960399 - Effects of chronic blockade of angiotensin ii receptor on the maintenance of hypertensi...
7883579 - Effectiveness of assistance circulations for distal circulatory support during cross-cl...
1559769 - Prostaglandin e in rabbit aqueous humor after nd-yag laser photodisruption of iris and ...
1858899 - Dynamics of intrarenal pressures and glomerular filtration rate after acetazolamide.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  14     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-23     Completed Date:  2001-12-07     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Aorta / physiopathology
Blood Pressure / drug effects,  physiology
Calcium / metabolism
Endothelium, Vascular / physiopathology*
Hypertension / pathology,  physiopathology*
Ion Channels / physiology*
Isoquinolines / pharmacology
Mesenteric Arteries / physiopathology
Myocardium / pathology
Organ Size
Patch-Clamp Techniques
Rats, Inbred SHR
Rats, Inbred WKY
Stroke / pathology,  physiopathology*
Vascular Resistance / physiology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Ion Channels; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 34SSX5LDE5/quinaprilat; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Voluntary running improves glucose tolerance and insulin resistance in female spontaneously hyperten...
Next Document:  Enhanced neutrophil superoxide anion production and its modification by beraprost sodium in spontane...