| Regulation of podocyte structure during the development of nephrotic syndrome. | |
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MedLine Citation:
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PMID: 9535550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nephrotic syndrome is a common kidney disease seen in both children and adults. The clinical syndrome includes massive proteinuria, hypoalbuminemia, edema, and usually hypercholesterolemia. Development of these clinical changes is closely correlated with profound structural changes in glomerular epithelial cells, or podocytes, which together with the glomerular basement membrane and endothelium comprise the kidney's blood filtration barrier. Although relatively little is known about the cellular or molecular changes which occur within podocytes during the development of nephrotic syndrome, cytoskeletal proteins very likely play a central role in these changes since they are primarily responsible for the maintenance of cell structure in almost all cells. This review focuses on: (a) the structure and function of podocytes in both the normal state and during nephrotic syndrome and (b) the potential roles of several cytoskeleton-associated proteins identified in podocytes in the development of and/or recovery from the pathophysiological cytoskeletal changes which occur in podocytes during nephrotic syndrome. |
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Authors:
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W E Smoyer; P Mundel |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: 76 ISSN: 0946-2716 ISO Abbreviation: J. Mol. Med. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-18 Completed Date: 1998-05-18 Revised Date: 2011-07-08 |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 172-83 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Michigan, Ann Arbor 48109-0684, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actinin
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physiology Cytoskeleton / physiology* Epithelial Cells Heat-Shock Proteins / physiology Humans Integrins / physiology Kidney Glomerulus / pathology* Nephrotic Syndrome / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins; 0/Integrins; 11003-00-2/Actinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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