| Regulation of plasma antidiuretic hormone in the dehydrated kangaroo rat (Dipodomys spectabilis M.). | |
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MedLine Citation:
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PMID: 3360285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A sensitive and specific radioimmunoassay was used to measure plasma antidiuretic hormone (plasma arginine vasopressin, PAVP) concentrations in a conscious desert-adapted mammal, the banner-tailed kangaroo rat (Dipodomys spectabilis; 131 +/- 2.3 g body mass), during normal hydration and in response to progressive dehydration. Simultaneous measurements of PAVP and plasma osmolality (POSM) in these experiments permitted determination of the hypothalamo-neurohypophyseal system-osmoreceptor set point and sensitivity to extracellular hyperosmolality during dehydration. In normally hydrated kangaroo rats, acclimated to room temperature (20-24 degrees) and fed a dry grain diet, POSM and PAVP averaged 308.6 +/- 0.7 mosmol/kg H2O and 6.0 +/- 0.7 pg/ml (2.2 +/- 0.2 microU/ml), respectively (means +/- SE). In separate groups of animals subjected to 48, 96, 144, or 192 hr of dehydration, POSM and PAVP increased in a parallel linear manner with time to maxima of 329.7 +/- 2.4 mosmol/kg H2O and 68.8 +/- 4.4 pg/ml (24.9 +/- 1.6 microU/ml), respectively, at 192 hr of dehydration. Thus, a highly correlated and significant relationship between POSM and PAVP (r2 = 0.941, P less than 0.001) exists in dehydrated kangaroo rats, quantitatively defined by the linear regression equation PAVP (pg/ml) = 2.99 (POSM - 306.4), with an apparent osmotic threshold for AVP release at a POSM of 306.4 mosmol/kg H2O.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J N Stallone; E J Braun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: General and comparative endocrinology Volume: 69 ISSN: 0016-6480 ISO Abbreviation: Gen. Comp. Endocrinol. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-06-02 Completed Date: 1988-06-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370735 Medline TA: Gen Comp Endocrinol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 119-27 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Tennessee, Memphis 38163. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / blood* Body Weight Dipodomys / blood* Electrolytes / blood Hematocrit / veterinary Osmolar Concentration Radioimmunoassay Rodentia / blood* Water Deprivation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AM-16294/AM/NIADDK NIH HHS; HL-07249/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 113-79-1/Arginine Vasopressin |
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