Document Detail

Regulation of plasma ANF after increases in afterload in conscious dogs.
MedLine Citation:
PMID:  2148058     Owner:  NLM     Status:  MEDLINE    
Although atrial stretch is the primary stimulus for atrial natriuretic factor (ANF) secretion, hormones may directly affect ANF secretion or may indirectly influence ANF by changing left ventricular afterload, thereby altering atrial stretch. To determine whether direct effects are important for the release of ANF in vivo, we measured changes in plasma ANF and in atrial wall function in the conscious dog after the administration of vasopressin, angiotensin II, and phenylephrine and by mechanically increasing left ventricular afterload by partial aortic occlusion. Injections of phenylephrine, angiotensin II, and arginine vasopressin (AVP) that were chosen to cause similar changes in systemic arterial pressure resulted in similar changes in atrial pressure and diameter. Maximum V wave atrial wall stress increased to 283 +/- 12, 311 +/- 41, 327 +/- 24, and 277 +/- 22 g/cm2 for AVP, angiotensin, phenylephrine, and occlusion, respectively, and plasma ANF increased to 242 +/- 81, 248 +/- 62, 299 +/- 95, and 190 +/- 53 pg/ml. There were significant linear correlations between left ventricular afterload and left atrial pressure, and each method for increasing left ventricular afterload shifted the position to the left on an atrial pressure-diameter, compliance curve, by a similar degree. Thus changes in left ventricular afterload result in changes in atrial wall function and similar changes in plasma ANF. No hormonal-specific increase in plasma ANF was found in conscious dogs after increases in afterload.
J M Stewart; J Wang; A Singer; G A Zeballos; M Ochoa; M B Patel; M H Gewitz; T H Hintze
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  259     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1736-42     Citation Subset:  IM    
Department of Physiology, New York Medical College, Valhalla 10595.
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MeSH Terms
Angiotensin II / pharmacology
Aorta / physiology
Arginine Vasopressin / pharmacology
Atrial Natriuretic Factor / blood*
Blood Pressure / drug effects
Cardiovascular System / drug effects
Heart / physiology*
Heart Ventricles
Phenylephrine / pharmacology
Regression Analysis
Grant Support
Reg. No./Substance:
11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 59-42-7/Phenylephrine; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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