Document Detail

Regulation of phosphatidylcholine metabolism in mammalian hearts.
MedLine Citation:
PMID:  2665794     Owner:  NLM     Status:  MEDLINE    
Phosphatidylcholine is the major phospholipid in the mammalian heart. Over 90% of the cardiac phosphatidylcholine is synthesized via the CDP-choline pathway. The rate-limiting step of this pathway is catalyzed by CTP:phosphocholine cytidylyltransferase. Current evidence suggests that phosphatidylcholine biosynthesis in the heart is regulated by the availability of CTP and the modulation of cytidylyltransferase activity. Phosphatidylcholine is degraded mainly by the actions of phospholipase A1 and A2, with the formation of lysophosphatidylcholine. Lysophosphatidylcholine may be further deacylated by lysophospholipase or reacylated back into the parent phospholipid by the action of acyltransferase. The accumulation of lysophosphatidylcholine in the heart may be one of the biochemical factors for the production of cardiac arrhythmias.
G M Hatch; K O; P C Choy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochemistry and cell biology = Biochimie et biologie cellulaire     Volume:  67     ISSN:  0829-8211     ISO Abbreviation:  Biochem. Cell Biol.     Publication Date:    1989 Feb-Mar
Date Detail:
Created Date:  1989-08-31     Completed Date:  1989-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606068     Medline TA:  Biochem Cell Biol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  67-77     Citation Subset:  IM    
Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Heart / physiology*
Mammals / metabolism*,  physiology
Myocardium / metabolism*
Phosphatidylcholines / metabolism*,  physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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