Document Detail

Regulation of peripheral metabolism by substrate partitioning in the brain.
MedLine Citation:
PMID:  23391240     Owner:  NLM     Status:  MEDLINE    
All organisms must adapt to changing nutrient availability, with nutrient surplus promoting glucose metabolism and nutrient deficit promoting alternative fuels (in mammals, mainly free fatty acids). A major function of glucose-sensing neurons in the hypothalamus is to regulate blood glucose. When these neurons sense glucose levels are too low, they activate robust counterregulatory responses to enhance glucose production, primarily from liver, and reduce peripheral metabolism. Some hypothalamic neurons can metabolize free fatty acids via β-oxidation, and β-oxidation generally opposes effects of glucose on hypothalamic neurons. Thus hypothalamic β-oxidation promotes obese phenotypes, including enhanced hepatic glucose output.
Cesar Moreno; Linda Yang; Penny Dacks; Fumiko Isoda; Michael Poplawski; Charles V Mobbs
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  42     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-11-07     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Fatty Acids, Nonesterified / metabolism*
Glucose / metabolism
Hypothalamus / cytology,  metabolism*
Liver / metabolism
Neurons / metabolism*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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