| Regulation of peripheral B cell maturation. | |
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MedLine Citation:
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PMID: 16797504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it is clear that the final phases of B cell maturation occur after newly formed B cells exit the bone marrow, the mechanisms underpinning the maturation, selection, and long-term survival of immature peripheral B cells remain poorly understood. Here, we review recent advances in our understanding of how B cell receptor (BCR)-mediated signaling events integrate with additional environmental cues to promote the selection and differentiation of immature B cells into functionally distinct subpopulations of mature B cells. We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells. |
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Authors:
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Matthew D Thomas; Bhaskar Srivastava; David Allman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-06-23 |
Journal Detail:
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Title: Cellular immunology Volume: 239 ISSN: 0008-8749 ISO Abbreviation: Cell. Immunol. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-07-17 Completed Date: 2006-08-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1246405 Medline TA: Cell Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 92-102 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6082, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocyte Subsets / cytology*, immunology, metabolism Cell Differentiation / immunology* Humans Receptors, Antigen, B-Cell / biosynthesis, physiology Signal Transduction / immunology |
| Grant Support | |
ID/Acronym/Agency:
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5T32HL007971/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, B-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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