Document Detail

Regulation of pancreatic beta-cell function by adipocytes.
MedLine Citation:
PMID:  17579776     Owner:  NLM     Status:  MEDLINE    
Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.
Yu-Feng Zhao; Chen Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Sheng li xue bao : [Acta physiologica Sinica]     Volume:  59     ISSN:  0371-0874     ISO Abbreviation:  Sheng Li Xue Bao     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-20     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  20730130R     Medline TA:  Sheng Li Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Endocrine Cell Biology, Prince Henry's Institute of Medical Research, Melbourne, VIC 3168, Australia.
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MeSH Terms
Adipocytes / physiology*
Adiponectin / physiology
Diabetes Mellitus, Type 2 / physiopathology
Glucose / metabolism
Insulin / pharmacology
Insulin-Secreting Cells / physiology*
Leptin / physiology
Lipid Metabolism
Reg. No./Substance:
0/Adiponectin; 0/Leptin; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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