Document Detail

Regulation of organ growth by morphogen gradients.
MedLine Citation:
PMID:  20182606     Owner:  NLM     Status:  MEDLINE    
Morphogen gradients play a fundamental role in organ patterning and organ growth. Unlike their role in patterning, their function in regulating the growth and the size of organs is poorly understood. How and why do morphogen gradients exert their mitogenic effects to generate uniform proliferation in developing organs, and by what means can morphogens impinge on the final size of organs? The decapentaplegic (Dpp) gradient in the Drosophila wing imaginal disc has emerged as a suitable and established system to study organ growth. Here, we review models and recent findings that attempt to address how the Dpp morphogen contributes to uniform proliferation of cells, and how it may regulate the final size of wing discs.
Gerald Schwank; Konrad Basler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  2     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-25     Completed Date:  2010-09-29     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a001669     Citation Subset:  IM    
Institute of Molecular Biology, University of Zurich.
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MeSH Terms
Body Patterning
Cell Cycle
Cell Proliferation
Drosophila / metabolism
Drosophila Proteins / metabolism
Gene Expression Regulation*
Gene Expression Regulation, Developmental
Intercellular Signaling Peptides and Proteins / metabolism*
Models, Biological
Reg. No./Substance:
0/Drosophila Proteins; 0/Intercellular Signaling Peptides and Proteins

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