Document Detail

Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor.
MedLine Citation:
PMID:  12056559     Owner:  NLM     Status:  MEDLINE    
Nociceptive dorsal root ganglion (DRG) cells can be divided into three main populations, namely (1) small diameter non-peptide-expressing cells, (2) small-diameter peptide-expressing (calcitonin gene related peptide (CGRP), substance P) cells, and (3) medium-diameter peptide-expressing (CGRP) cells. The properties of these cell populations will be reviewed, with a special emphasis on the expression of the vanilloid (capsaicin) receptor VR1 and its regulation by growth factors. Cells in populations 1 and 2 express VR1, a nonselective channel that transduces certain nociceptive stimuli and that is crucial to the functioning of polymodal nociceptors. Cells in population 1 can be regulated by glial cell line derived neurotrophic factor (GDNF) and those in populations 2 and 3 by nerve growth factor (NGF). In vivo, DRG cells express a range of levels of VR1 expression and VR1 is downregulated after axotomy. However, treatment with NGF or GDNF can prevent this downregulation. In vitro, DRG cells also show a range of VR1 expression levels that is NGF and (or) GDNF dependent. Functional studies indicate that freshly dissociated cells also show differences in sensitivity to capsaicin. The significance of this is not known but may indicate a difference in the physiological role of cells in populations 1 and 2.
J V Priestley; G J Michael; S Averill; M Liu; N Willmott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  80     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-11     Completed Date:  2002-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  495-505     Citation Subset:  IM    
Department of Neuroscience, Bart and The London, School of Medicine and Dentistry, Queen Mary University of London, England. J.V.PRIESTLEY@QMW.AC.UK
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MeSH Terms
Afferent Pathways / drug effects,  metabolism
Cannabinoids / biosynthesis
Ganglia, Spinal / drug effects,  metabolism
Glial Cell Line-Derived Neurotrophic Factor
Nerve Growth Factor / metabolism,  pharmacology*
Nerve Growth Factors / metabolism,  pharmacology*
Neuroglia / physiology*
Neurons / drug effects,  metabolism*
Nociceptors / metabolism*
Receptors, Drug / biosynthesis
Reg. No./Substance:
0/Cannabinoids; 0/GDNF protein, human; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Nerve Growth Factors; 0/Receptors, Drug; 9061-61-4/Nerve Growth Factor

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