| Regulation of nitric oxide synthase gene expression by cytokines. | |
| | |
MedLine Citation:
|
PMID: 8951577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Evidence is presented that not only macrophage type of NO synthase but also endothelial constitutive type of NO synthase genes are regulated by a variety of exogenous stimuli including cytokines. It is possible that pathophysiological concentrations of TNF-alpha noted in some patients with congestive heart failure may be sufficient to decrease levels for the constitutive form of NO synthase and increase those for the inducible form of NO synthase. Interestingly, chronic exercise in dogs was demonstrated to increases coronary vascular NO production and steady-state mRNA levels of ecNO synthase. Endogenous NO plays a crucial role in modulating vascular tone and inhibiting interactions of the vessel wall with circulating blood elements such as platelets, monocytes and neutrophils. It is possible that alterations in its synthesis or activity may play an important role in some cardiovascular disorders including congestive heart failure. Further studies of the pathophysiological significance of NO in specific experimental and clinical settings of congestive heart failure may provide a basis for improved therapeutic measures to enhance the synthesis or effect of endogenous NO, or to supplement its activity with exogenous NO donors or superoxide scavengers. |
| | |
Authors:
|
M Yokoyama; K Hirata; S Kawashima; Y Kawahara |
Related Documents
:
|
21036777 - Submaximal exercise gas exchange is an important prognostic tool to predict adverse out... 2901957 - Effect of vasodilator and inotropic drugs on clinical symptoms and long-term survival i... 1329477 - Long-acting angiotensin-converting enzyme inhibition: once-daily lisinopril versus twic... 16520257 - Improvement of exercise-induced cardiac deformation after cell therapy for severe chron... 1890967 - Exercise as prevention: do the health benefits derive in part from lower iron levels? 9220677 - Time of host-seeking by culex tarsalis (diptera:culicidae) in california. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of cardiac failure Volume: 2 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-03-13 Completed Date: 1997-03-13 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: S179-85 Citation Subset: IM |
Affiliation:
|
First Department of Medicine, Kobe University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiovascular Diseases / enzymology Cytokines / physiology* Dogs Gene Expression Regulation, Enzymologic / physiology* Nitric Oxide Synthase / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of tumor necrosis factor-alpha on cardiac structure and function: a tale of two cytokines...
Next Document: Newer aspects of pathogenesis of heart failure: hepatitis C virus infection in myocarditis and cardi...