Document Detail

Regulation of neuronal diversity in the Xenopus retina by Delta signalling.
MedLine Citation:
PMID:  8985247     Owner:  NLM     Status:  MEDLINE    
To generate the variety of mature neurons and glia found in the developing retina, the competence of pluripotent progenitor cells to respond to extracellular signals must be controlled. Delta, a ligand of the Notch receptor, is a candidate for regulating progenitor competence on the grounds that activation of the pathway involving Notch and Delta can inhibit cellular differentiation. Here we test this possibility in the developing Xenopus retina by misexpression of Delta messenger RNA. We find that Delta-misexpressing cells with wild-type neighbours adopt earlier fates, primarily becoming ganglion cells and cone photoreceptors. Progenitors transfected with Delta later in development also produce rod photoreceptors, but not the latest-generated cell types, demonstrating the importance of timing in Delta function. We conclude that Delta signalling in the vertebrate retina is a basic regulatory mechanism that can be used to generate neuronal diversity.
R I Dorsky; W S Chang; D H Rapaport; W A Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  385     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-01-23     Completed Date:  1997-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Department of Biology, University of California, San Diego, California 92093, USA.
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MeSH Terms
Cell Differentiation / physiology
Clone Cells
Membrane Proteins / genetics,  metabolism*
Neurons / physiology*
RNA, Messenger
Receptors, Cell Surface / metabolism
Receptors, Notch
Retina / cytology*,  embryology
Signal Transduction*
Stem Cells / physiology
Reg. No./Substance:
0/Membrane Proteins; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Receptors, Notch; 0/delta protein

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