| Regulation of myocardial triacylglycerol synthesis and metabolism. | |
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MedLine Citation:
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PMID: 14643794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies showing a correlation of excess myocardial triacylglycerol stores with apoptosis, fibrosis, and contractile dysfunction indicate that dysregulation of triacylglycerol metabolism may contribute to cardiac disease. This review covers the regulation of heart triacylglycerol accumulation at the critical control points of fatty acid uptake, enzymes of triacylglycerol synthesis, lipolysis, and lipoprotein secretion. These pathways are discussed in the context of the central role myocardial triacylglycerol plays in cardiac energy metabolism and heart disease. |
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Authors:
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Tal M Lewin; Rosalind A Coleman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1634 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-01-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 63-75 Citation Subset: IM |
Affiliation:
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Department of Nutrition, School of Public Health, University of North Carolina, CB #7400, Pittsboro Street, Chapel Hill, NC 27599, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids / metabolism Humans Lipolysis Lipoproteins / biosynthesis, secretion Myocardium / metabolism* Triglycerides / biosynthesis*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK56598/DK/NIDDK NIH HHS; DK59931/DK/NIDDK NIH HHS; DK59935/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Lipoproteins; 0/Triglycerides |
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