| Regulation of murine telomere length via Rtel. | |
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MedLine Citation:
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PMID: 15588516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal somatic cells have a finite replicative capacity. With each cell division, telomeres (the physical ends of linear chromosomes) progressively shorten until they reach a critical length, at which point the cells enter replicative senescence. Some cells can maintain telomere length by the action of the telomerase enzyme. A recent article described in detail the organization and function of Rtel, a murine gene encoding a DNA helicase-like protein. The Rtel protein was found to be essential for genomic stability and embryonic development and survival, and is proposed to be a dominant regulator of murine telomere length. |
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Authors:
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Barry Flanary |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rejuvenation research Volume: 7 ISSN: 1549-1684 ISO Abbreviation: Rejuvenation Res Publication Date: 2004 |
Date Detail:
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Created Date: 2004-12-13 Completed Date: 2005-02-01 Revised Date: 2007-09-11 |
Medline Journal Info:
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Nlm Unique ID: 101213381 Medline TA: Rejuvenation Res Country: United States |
Other Details:
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Languages: eng Pagination: 168-70 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, 100 Newell Dr., L1-100, Gainesville, FL 32610-0244, USA. beflana@ufl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Aging / genetics* Cell Division DNA Helicases / genetics* Genes, Essential* Genes, Regulator Mice Muridae / genetics Telomere / physiology* |
| Chemical | |
Reg. No./Substance:
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EC 3.6.1.-/DNA Helicases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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