Document Detail

Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo 31P NMR spectroscopy.
MedLine Citation:
PMID:  12881208     Owner:  NLM     Status:  MEDLINE    
Image-guided, spatially localized 31P magnetic resonance spectroscopy (MRS) was used to study in vivo murine cardiac metabolism under resting and dobutamine-induced stress conditions. Intravenous dobutamine infusion (24 mug. min-1. kg body wt-1) increased the mean heart rate by approximately 39% from 482 +/- 46 per min at baseline to 669 +/- 77 per min in adult mice. The myocardial phosphocreatine (PCr)-to-ATP (PCr/ATP) ratio remained unchanged at 2.1 +/- 0.5 during dobutamine stress, compared with baseline conditions. Therefore, we conclude that a significant increase in heart rate does not result in a decline in the in vivo murine cardiac PCr/ATP ratio. These observations in very small mammals, viz., mice, at extremely high heart rates are consistent with studies in large animals demonstrating that global levels of high-energy phosphate metabolites do not regulate in vivo myocardial metabolism during physiologically relevant increases in cardiac work.
A V Naumova; R G Weiss; V P Chacko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-07-24
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  285     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-16     Completed Date:  2003-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1976-9     Citation Subset:  IM    
Department of Radiology, Magnetic Resonance Research Division, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.
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MeSH Terms
Adenosine Triphosphate / metabolism
Adrenergic beta-Agonists / pharmacology*
Body Constitution
Dobutamine / pharmacology*
Energy Metabolism / drug effects*,  physiology*
Heart Rate
Magnetic Resonance Spectroscopy
Myocardium / metabolism*
Phosphocreatine / metabolism
Phosphorus Isotopes / diagnostic use
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Phosphorus Isotopes; 34368-04-2/Dobutamine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

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