| Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo 31P NMR spectroscopy. | |
| | |
MedLine Citation:
|
PMID: 12881208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Image-guided, spatially localized 31P magnetic resonance spectroscopy (MRS) was used to study in vivo murine cardiac metabolism under resting and dobutamine-induced stress conditions. Intravenous dobutamine infusion (24 mug. min-1. kg body wt-1) increased the mean heart rate by approximately 39% from 482 +/- 46 per min at baseline to 669 +/- 77 per min in adult mice. The myocardial phosphocreatine (PCr)-to-ATP (PCr/ATP) ratio remained unchanged at 2.1 +/- 0.5 during dobutamine stress, compared with baseline conditions. Therefore, we conclude that a significant increase in heart rate does not result in a decline in the in vivo murine cardiac PCr/ATP ratio. These observations in very small mammals, viz., mice, at extremely high heart rates are consistent with studies in large animals demonstrating that global levels of high-energy phosphate metabolites do not regulate in vivo myocardial metabolism during physiologically relevant increases in cardiac work. |
| | |
Authors:
|
A V Naumova; R G Weiss; V P Chacko |
Related Documents
:
|
15336798 - History of the evolution of echocardiography. 8219818 - Mental stress and myocardial ischemia. correlates and potential interventions. 581958 - Effects of dobutamine on coronary circulation and cardiac metabolism of the dog. 15757608 - Efficacy and safety of intermittent, long-term, concomitant dobutamine and levosimendan... 15844828 - Hawthorn: potential roles in cardiovascular disease. 1791618 - What does the future hold for ace inhibitors? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-07-24 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 285 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2003 Nov |
Date Detail:
|
Created Date: 2003-10-16 Completed Date: 2003-11-21 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H1976-9 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Magnetic Resonance Research Division, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
metabolism Adrenergic beta-Agonists / pharmacology* Animals Body Constitution Dobutamine / pharmacology* Energy Metabolism / drug effects*, physiology* Heart Rate Magnetic Resonance Spectroscopy Mice Myocardium / metabolism* Phosphocreatine / metabolism Phosphorus Isotopes / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
|
HL 63030-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Agonists; 0/Phosphorus Isotopes; 34368-04-2/Dobutamine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxidized low-density lipoprotein and 15-deoxy-delta 12,14-PGJ2 increase mitochondrial complex I acti...
Next Document: Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus.