| Regulation mode of evaporative cooling underlying a strategy of the heat-tolerant FOK rat for enduring ambient heat. | |
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MedLine Citation:
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PMID: 12969873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compared with other rat strains, the inbred FOK rat is extremely heat tolerant. This increased heat tolerance is due largely to the animal's enhanced saliva spreading abilities. The aims of the present study were to 1) quantify the heat tolerance capacity of FOK rats and 2) determine the regulatory mode of the enhanced salivary cooling in these animals. Various strains of rats were acutely exposed to heat. In the heat-intolerant strains, saliva spreading was insufficient and the core temperature (Tc) rose rapidly. In contrast, FOK rats maintained an elevated Tc plateau (39.5 +/- 0.7 degrees C) for 5-6 h over a wide range of ambient temperatures (Ta) (37.5-42.5 degrees C). In hot environments the FOK rats secreted copious amounts of saliva and spread it over more than the entire ventral body surface. FOK rats had a low Tc threshold for salivation, and the salivation rate increased linearly in proportion to the Tc deviation from the threshold. No strain difference or temperature effect was observed in the saliva secretion rate from in vitro submandibular glands perfused by sufficient doses of ACh. These results suggest that 1) the ability of FOK rats to maintain a moderate steady-state hyperthermia (39.5 +/- 0.7 degrees C) over a wide Ta range is enabled by a lowered threshold Tc for salivation and functional negative-feedback control of saliva secretion and 2) strain differences in ability to endure heat stress are mainly attributable to changes in the thermoregulatory control system rather than altered secretory abilities of the salivary glands. |
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Authors:
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Fujiya Furuyama; Masataka Murakami; Etsuro Tanaka; Hideki Hida; Daisuke Miyazawa; Takanori Oiwa; Yoshiaki Isobe; Hitoo Nishino |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2003-09-11 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 285 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-01-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1439-45 Citation Subset: IM; S |
Affiliation:
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Department of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya 467-8601, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Animals Behavior, Animal Body Temperature Regulation / physiology* Heat Stress Disorders / genetics, physiopathology* Hot Temperature Male Rats Rats, Inbred ACI Rats, Sprague-Dawley Salivation / physiology* Species Specificity Submandibular Gland / physiology, secretion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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