Document Detail

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast.
MedLine Citation:
PMID:  2320127     Owner:  NLM     Status:  MEDLINE    
The coordination of somatic cell division with cell size must be accomplished by the accumulation of mitotic inducers or the dilution, in the course of cell growth, of mitotic inhibitors. In fission yeast (Schizosaccharomyces pombe), cell size at mitosis is determined by expression of the cdc25+ and nim1+ inducer genes and of the inhibitor gene wee1+, which between them regulate the M-phase protein kinase p34cdc2. We now report that both the phosphoprotein product of cdc25+ (p80cdc25, with apparent relative molecular mass 80,000) and the corresponding messenger RNA increase in concentration as cells proceed through interphase, peaking at mitosis. We propose that the cell-cycle timing of mitosis in somatic cells is regulated by the cyclic accumulation of the cdc25 mitotic inducer, which on reaching a critical level results in activation of p34cdc2 protein kinase. Accumulation of this inducer could play a part in coordinating cell division with growth.
S Moreno; P Nurse; P Russell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  344     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-07     Completed Date:  1990-05-07     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  549-52     Citation Subset:  IM    
Department of Biochemistry, University of Oxford, UK.
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MeSH Terms
Cell Cycle Proteins*
Cell Division
Fungal Proteins / biosynthesis*,  genetics
Gene Expression Regulation
Molecular Weight
RNA, Messenger / metabolism
Saccharomycetales / metabolism*
Schizosaccharomyces / cytology,  genetics,  metabolism*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Fungal Proteins; 0/RNA, Messenger; 0/ras-GRF1

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