Document Detail

Regulation of methotrexate polyglutaminate formation in Ehrlich ascites carcinoma cells by endogenous folate pool.
MedLine Citation:
PMID:  2424199     Owner:  NLM     Status:  MEDLINE    
The conversion of methotrexate to poly-gamma-glutamyl derivatives in Ehrlich ascites carcinoma cells which are characterized by different pools of endogenous folates is described. The cells in which folate pool was high (the 5-fluorodeoxy-uridine-resistant cell line) the ability to convert methotrexate to its polyglutamate derivatives was much lower than in the cells in which folate pool was smaller (the parental cell line). When the cellular folate pool was reduced by treatment of the cells with lysolecithin, a similar methotrexate polyglutamate concentration in both cell lines was observed. These data suggest that cellular folate pool has a regulatory effect on methotrexate polyglutamate synthesis.
M Balińska
Related Documents :
14149399 - Reevaluation of assays used to show rna induction of glucose-6-phosphatase in ascites c...
2817819 - Treatment of mice bearing a krebs ascitic tumor by means of a protocol based on radioac...
6831629 - Increased uptake of actinomycin d in ehrlich ascites tumour cells induced by daunorubicin.
2424199 - Regulation of methotrexate polyglutaminate formation in ehrlich ascites carcinoma cells...
19196399 - Intervention of pyrrolidine dithiocarbamate and tetrandrine on cellular calcium overloa...
2576649 - Sodium butyrate enhances the activities of membranal enzymes and increases drug sensiti...
3265929 - Murine hybrid cell lines expressing the nldc-145 dendritic cell determinant.
23710609 - Mir-145 inhibits oral squamous cell carcinoma (oscc) cell growth by targeting c-myc and...
8102339 - A novel adherence assay for bordetella pertussis using tracheal organ cultures.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  33     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carcinoma, Ehrlich Tumor / metabolism*
Folic Acid / metabolism*
Methotrexate / analogs & derivatives*,  biosynthesis,  isolation & purification,  metabolism
Peptide Biosynthesis*
Polyglutamic Acid / analogs & derivatives,  biosynthesis*,  isolation & purification
Reg. No./Substance:
25513-46-6/Polyglutamic Acid; 59-05-2/Methotrexate; 59-30-3/Folic Acid; 82334-40-5/methotrexate polyglutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Development and trial of a heterogenous antistaphylococcal gamma-globulin
Next Document:  Long-term sotalol therapy in patients with ventricular arrhythmias.