Document Detail

Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise.
MedLine Citation:
PMID:  15814608     Owner:  NLM     Status:  MEDLINE    
Endurance exercise improves insulin sensitivity and increases fat oxidation, which are partly facilitated by the induction of metabolic transcription factors. Next to exercise, increased levels of FFA's also increase the gene expression of transcription factors, hence making it difficult to discern the effects from contractile signals produced during exercise, from those produced by increased circulatory FFA's. We aimed to investigate, in human skeletal muscle, whether acute exercise affects gene expression of metabolic transcriptional co-activators and transcription factors, including PGC-1alpha, PRC, PPARalpha, beta/delta, and gamma and RXR, SREBP-1c and FKHR, and to discern the effect of exercise per se from those of elevated levels of FFA. Two hours of endurance exercise was performed either in the fasted state, or following carbohydrate ingestion prior to and during exercise, thereby blunting the fasting-induced increase in FA availability and oxidation. Of the genes measured, PGC-1alpha and PRC mRNA increased immediately after, while PPARbeta/delta and FKHR mRNA increased 1-4 h after exercise, irrespective of the increases in FFA's. Our results suggest that the induction in vivo of metabolic transcription factors implicated in mitochondrial biogenesis are under the control of inherent signals, (PGC-1alpha, PRC), while those implicated in substrate selection are under the control of associated signals (PPARbeta/delta, FKHR) stimulated from the contracting skeletal muscle that are independent of circulating FFA levels.
Aaron P Russell; Matthijs K C Hesselink; Sing Kai Lo; Patrick Schrauwen
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Publication Detail:
Type:  Journal Article     Date:  2005-04-06
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  19     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2006-02-17     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  986-8     Citation Subset:  IM    
Clinique Romande de Réadaptation SUVA Care, Sion, Switzerland.
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MeSH Terms
Dietary Carbohydrates / administration & dosage
Exercise / physiology*
Fatty Acids, Nonesterified / blood
Forkhead Transcription Factors / genetics
Gene Expression Regulation / physiology*
Heat-Shock Proteins / genetics
Muscle Contraction / physiology
Muscle, Skeletal / metabolism
PPAR gamma / genetics
PPAR-beta / genetics
Physical Endurance / physiology
RNA, Messenger / analysis
Trans-Activators / genetics*
Transcription Factors / genetics*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/FOXO1 protein, human; 0/Fatty Acids, Nonesterified; 0/Forkhead Transcription Factors; 0/Heat-Shock Proteins; 0/PPAR gamma; 0/PPAR-beta; 0/PPARGC1A protein, human; 0/RNA, Messenger; 0/Trans-Activators; 0/Transcription Factors; 0/peroxisome-proliferator-activated receptor-gamma coactivator-1

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