Document Detail

Regulation of the maximal rate of RNA synthesis in the fission yeast Schizosaccharomyces pombe.
MedLine Citation:
PMID:  6580524     Owner:  NLM     Status:  MEDLINE    
Of interest to many biologists is how growth, e.g., RNA synthesis, and cell division are mutually controlled. One method of establishing the nature of the control is to determine what "factors" are limiting when cells synthesize RNA at a maximal rate. The transcription maximum (maximum rate of RNA synthesis) has been determined in cell division mutants that continue to grow but fail to divide to determine if there is a cell cycle control over RNA synthesis. There is no correlation between transcription maximum and DNA synthesis or septation which suggests that these events do not exert a direct cell cycle control over RNA synthesis in exponentially growing cells. In addition, the lack of strong correlation between the transcription maximum and cell size or gene dosage indicates that the rate of RNA synthesis is not directly regulated by either of these parameters. The possibility that the maximum rate is determined by a concentration effect of an end product which acts in the nucleus, such as a specific RNA or protein, could not be ruled out and evidence is presented in support of such a model.
S G Elliott
Related Documents :
8774904 - Identification of in vivo target rna sequences bound by thymidylate synthase.
6864884 - Reduced synthesis of sindbis virus negative strand rna in cultures treated with host tr...
8368314 - Decreased expression of protooncogenes c-fos, c-myc, and c-jun following polyamine depl...
21412254 - Testicular germ cell tumours: predisposition genes and the male germ cell niche.
23252974 - Patterning and cell fate in the inner ear: a case for notch in the chicken embryo.
18333844 - A strategy of splitting individual high volume cord blood units into two half subunits ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular & general genetics : MGG     Volume:  192     ISSN:  0026-8925     ISO Abbreviation:  Mol. Gen. Genet.     Publication Date:  1983  
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0125036     Medline TA:  Mol Gen Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ascomycota / metabolism*
Cell Division
DNA, Fungal / biosynthesis
Genes, Fungal
RNA, Fungal / biosynthesis*
Schizosaccharomyces / genetics,  metabolism*
Transcription, Genetic
Reg. No./Substance:
0/DNA, Fungal; 0/RNA, Fungal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Coordination of growth with cell division: regulation of synthesis of RNA during the cell cycle of t...
Next Document:  Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic...