Document Detail


Regulation of maternal mRNAs in early development.
MedLine Citation:
PMID:  18365862     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most sexually reproducing metazoans are anisogamous, meaning that the two gametes that combine during fertilization differ greatly in size. By convention, the larger gametes are considered female and are called ova, while the smaller gametes are male and are called sperm. In most cases, both gametes contribute similarly to the chromosomal content of the new organism. In contrast, the maternal gamete contributes nearly all of the cytoplasm. This cytoplasmic contribution is crucial to patterning early development; it contains the maternal proteins and transcripts that guide the early steps of development prior to the activation of zygotic transcription. This review compares and contrasts early development in common laboratory model organisms in order to highlight the similarities and differences in the regulation of maternal factors. We will focus on the production and reversible silencing of maternal mRNAs during oogenesis, their asymmetric activation after fertilization, and their subsequent clearance at the midblastula transition. Where possible, insights from mechanistic studies are presented.
Authors:
Brian M Farley; Sean P Ryder
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in biochemistry and molecular biology     Volume:  43     ISSN:  1549-7798     ISO Abbreviation:  Crit. Rev. Biochem. Mol. Biol.     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8903774     Medline TA:  Crit Rev Biochem Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-62     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. Sean.Ryder@umassmed.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics
Embryonic Development / genetics*
Gene Expression Regulation, Developmental / genetics*
Oogenesis / genetics
RNA Processing, Post-Transcriptional
RNA, Messenger, Stored / genetics*
Grant Support
ID/Acronym/Agency:
NS059380/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger, Stored

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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