| Regulation of mast cell responses in health and disease. | |
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MedLine Citation:
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PMID: 22321108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection. They are also thought to play a role in angiogenesis, tissue remodeling, wound healing, and tumor repression or growth. The broad scope of these physiologic and pathologic roles illustrates the flexible nature of mast cells, which is enabled in part by their phenotypic adaptability to different tissue microenvironments and their ability to generate and release a diverse array of bioactive mediators in response to multiple types of cell-surface and cytosolic receptors. There is increasing evidence from studies in cell cultures that release of these mediators can be selectively modulated depending on the types or groups of receptors activated. The intent of this review is to foster interest in the interplay among mast cell receptors to help understand the underlying mechanisms for each of the immunological and non-immunological functions attributed to mast cells. The second intent of this review is to assess the pathophysiologic roles of mast cells and their products in health and disease. Although mast cells have a sufficient repertoire of bioactive mediators to mount effective innate and adaptive defense mechanisms against invading microorganisms, these same mediators can adversely affect surrounding tissues in the host, resulting in autoimmune disease as well as allergic disorders. |
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Authors:
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Alasdair M Gilfillan; Michael A Beaven |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Critical reviews in immunology Volume: 31 ISSN: 1040-8401 ISO Abbreviation: Crit. Rev. Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2012-02-10 Completed Date: 2012-04-26 Revised Date: 2013-02-27 |
Medline Journal Info:
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Nlm Unique ID: 8914819 Medline TA: Crit Rev Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 475-529 Citation Subset: IM |
Affiliation:
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Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA. agilfillan@niaid.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Ligands Mast Cells / immunology*, metabolism Phenotype Receptors, G-Protein-Coupled / immunology Receptors, Immunologic / immunology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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ZIA AI000967-06/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Receptors, G-Protein-Coupled; 0/Receptors, Immunologic |
| Comments/Corrections | |
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