| Regulation of lymphocyte growth by antagonists of interleukin-2 or its cellular receptor. | |
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MedLine Citation:
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PMID: 3134498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dependence of T cell proliferation on the production, binding and utilization of the lymphokine growth factor IL-2 has fostered the development and testing of new classes of drugs which act to either inhibit IL-2 production or the interaction of IL-2 with its cellular receptor. We have reviewed evidence which documents the potent immunosuppressive effects of inhibitors of IL-2 synthesis and secretion, such as Ciclosporin A, and of anti-IL-2 receptor MAb. The similarities of the potency and specificity of these agents and their effectiveness in a wide range of clinical settings encourage further studies on their mechanism of action. Perhaps the most dramatic similarity is the induction of long-term nonresponsiveness after drug removal to antigens present at the time of drug therapy. This observation has profound importance both on clinical manipulation with these agents and n the origins and maintenance of self-tolerance. |
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Authors:
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G N Gaulton; J F Markmann |
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Publication Detail:
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Type: In Vitro; Journal Article; Review |
Journal Detail:
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Title: Immunologic research Volume: 7 ISSN: 0257-277X ISO Abbreviation: Immunol. Res. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-08-19 Completed Date: 1988-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 113-35 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / therapeutic use Cyclosporins / pharmacology Graft Survival / drug effects Humans Immunosuppression Interleukin-2 / biosynthesis, immunology* Lymphocyte Activation* Mice Receptors, Immunologic / immunology Receptors, Interleukin-2 T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Cyclosporins; 0/Interleukin-2; 0/Receptors, Immunologic; 0/Receptors, Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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