| Regulation of liver diphosphofructose phosphatase of the rat and hamster. | |
| | |
MedLine Citation:
|
PMID: 165727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The regulatory properties of D-fructose-1, 6-diphosphate 1-phosphohydrolase (FDPase, EC 3.1.3.11) derived from livers of the albino rat and the golden Syrian hamster have been studies. The comparative analysis of the kinetics of saturation by fructose-1, l-diphosphate (FDP) and inhibition by FDP and by the allosteric ligand adenosine 5'-monophosphate (AMP) revealed differences that may have physiological implications. The inhibition studies pointed out that liver phosphatase is under a significantly less stringent regulation in the hibernating rodent. The concentration of AMP required to produce a 50 percent inhibition was 549.5 muM at 37 degrees C, 21.4 muM at 10 degrees C, and 9.2 muM at 5 percent C for the rat; 1,122 muM at 37 degrees C, 34.3 muM at 10 degrees C, and 20.4 muM at 5 degrees C for the hamster. Urea (0.67 M) simulates the effect of low temperature, potentiating the AMP inhibition. At 5 degrees C and 4 M urea, 75 percent loss of activity was found for the rat FDPase in contrast to a 25 percent loss for the hamster. At 37 degrees C, 4 M urea had practically no effect on the FDPase of both species. |
| | |
Authors:
|
A Orengo |
Related Documents
:
|
2576727 - Thermal salivation in rats, anesthetized with barbiturates, chloralose, urethane and ke... 1205557 - Effects of heat--stress in rats: critical period and reduced survival of post-implantat... 834467 - Antagonism of cadmium and alloxan-induced hyperglycemia in rats by trigonella foenum gr... 15323767 - Measurement of the hall dynamo effect during magnetic reconnection in a high-temperatur... 12459927 - Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and g... 21918527 - Cardiac remodeling and diastolic dysfunction in dahls.z-lepr(fa)/lepr(fa) rats: a new a... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 228 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Apr |
Date Detail:
|
Created Date: 1975-07-18 Completed Date: 1975-07-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1118-22 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Monophosphate
/
metabolism Allosteric Regulation Animals Cricetinae / metabolism* Depression, Chemical Female Fructose-Bisphosphatase / metabolism* Fructosephosphates / metabolism Kinetics Liver / enzymology* Rats / metabolism* Stimulation, Chemical Temperature Urea / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Fructosephosphates; 57-13-6/Urea; 61-19-8/Adenosine Monophosphate; EC 3.1.3.11/Fructose-Bisphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypothalamic cells in an area mediating ACTH release respond to right atrial stretch.
Next Document: Afferent aortic nerve fibers with their pathways in cardiac sympathetic nerves.