Document Detail

Regulation of lipid metabolism by dipyridamole and adenosine antagonists in rat adipocytes.
MedLine Citation:
PMID:  2583356     Owner:  NLM     Status:  MEDLINE    
1. Acute effects of dipyridamole, an inhibitor of adenosine transport, direct activators of adenylate cyclase and thirteen adenosine antagonist analogs on fatty acid synthesis have been examined in terms of the control of [1-14C]acetate incorporation into labeled fatty acids in the presence of glucose. 2. This monosaccharide acts as a stimulator of lipogenesis by generating NADPH for the lipid synthesis. 3. The relationship between lipogenesis and lipolysis was compared with a variety of adenylate cyclase stimulators. 4. The data obtained reveals that dipyridamole potentiated the inhibitory or stimulatory effects of isoproterenol and forskolin on lipogenesis and on lipolysis, respectively. 5. In these cases the data show that it exists an inverse relationship between lipogenesis and lipolysis. 6. Dipyridamole and methylxanthine analogs only moderately affect the rate of lipolysis whereas its effects are more potent on lipogenesis and lend further support to the hypothesis that dipyridamole antagonize adenosine actions as well as methyl xanthines. 7. These results suggest that dipyridamole and adenosine antagonists alter lipogenesis independently of the lipolytic process and that it exists an inverse relationship between lipogenesis and lipolysis under some conditions whereas there are not under others.
J González-Nicolás; J Jiménez; A Page-Pañuelas; M T Zabala; F J Moreno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  21     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1989  
Date Detail:
Created Date:  1990-01-11     Completed Date:  1990-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  883-8     Citation Subset:  IM    
Departamento de Biología Molecular, Facultad de Ciencias, Universidad Autónoma-C.S.I.C., Madrid, España.
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MeSH Terms
Adenosine / antagonists & inhibitors*
Adenylate Cyclase / metabolism
Adipose Tissue / cytology,  drug effects*,  metabolism
Cells, Cultured
Dipyridamole / pharmacology*
Enzyme Activation / drug effects
Forskolin / pharmacology
Isoproterenol / pharmacology
Lipid Metabolism*
Lipolysis / drug effects
Rats, Inbred Strains
Xanthines / pharmacology
Reg. No./Substance:
0/Xanthines; 58-32-2/Dipyridamole; 58-61-7/Adenosine; 66428-89-5/Forskolin; 7683-59-2/Isoproterenol; EC Cyclase

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