Document Detail

Regulation of intracranial pressure in the rat with chronic moderate hypercapnia.
MedLine Citation:
PMID:  10418724     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: In this animal study we investigated whether CO2-induced intracranial hypertension was sustained in chronic hypercapnia. DESIGN: We kept five rats in a 10% CO2-air mixture (PaCO2 73.4 +/- 6.2 Torr, mean +/- 1SD) for 22 weeks, and then measured the rats' intracranial pressure while breathing the 10% CO2- air mixture or the room air. RESULTS: The intracranial pressures recorded during chronic hypercapnia in systole and diastole were 7.0 +/- 1.9 and 5.4 +/- 1.6 mm Hg, respectively. When the rats were acutely exposed to the room air (PaCO2, 51.9 +/- 10.2 Torr), the intracranial pressures in systole and diastole were 6.1 +/- 1.4 and 5.0 +/- 0.8 mm Hg, respectively, were not significantly different from those during hypercapnia (P>0.05, paired t-test). CONCLUSIONS: The intracranial pressure in rats with chronic moderate hypercapnia was not significantly different from normocapnic rats, and this change was associated with a blunting of intracranial pressure autoregulation.
M Kumagai; T Kondo; F Takei; I Kanayama; Y Ohta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Tokai journal of experimental and clinical medicine     Volume:  23     ISSN:  0385-0005     ISO Abbreviation:  Tokai J. Exp. Clin. Med.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-09-24     Completed Date:  1999-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704186     Medline TA:  Tokai J Exp Clin Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM; S    
Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
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MeSH Terms
Blood Gas Analysis
Blood Pressure
Carbon Dioxide
Chronic Disease
Hypercapnia / physiopathology*
Intracranial Pressure / physiology*
Rats, Wistar
Reg. No./Substance:
124-38-9/Carbon Dioxide

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